Affliction hoodies

Affliction's clothing line includes t-shirts, polo shirts, thermals, and hoodies. Their style has been described as "skull and crossbone inspired". Many of Affliction's shirts bear the logo of many of the world's top ranked MMA fighters, including: Georges St. Pierre, Randy Couture, and Quinton Jackson.

Its products are also worn and promoted by top boxers, such as current undisputed middleweight champion of the world, Kelly Pavlik, Ring magazine and IBO light welterweight champion Ricky Hatton, and by former undisputed middleweight champion of the world and hall-of-famer Bernard Hopkins, And also current WBA welterweight champion Antonio Margarito

Affliction's clothing line is also often seen being worn by WWE's Edge, Undertaker, Stone Cold Steve Austin, Matt Hardy, Chavo Guerrero Jr, and Randy Orton. Also some TNA Superstars like Samoa Joe, Christian Cage, and AJ Styles wear these clothes. Avenged Sevenfold frontman M. Shadows is often seen sporting the latest Affliction T-shirts.

Several nightclubs and bars in Vancouver & Victoria do not allow Affliction's clothing in addition to other labels such as Ed Hardy due to a perceived association with local gang activities. Pamela Rogers, a spokesperson for Affliction, maintained that the brand "has nothing to do with gangs" and describes it instead as an "upscale men’s boutique brand".